Statement of Purpose

Applicant:XXX (Nankai University)          Program:Ph.D. in Biochemistry

Abstract: In this present Statement of Purpose, I intend to present my passion for biochemistry, the endeavors and achievements I have made heretofore in my academic journey to become a research student, my preparations for the proposed Ph.D. program, and my vision for the future. My conclusion is that, whereas in research I can arrive at effective findings as long as I am given necessary conditions, in my personal and academic development I can become an accomplished biochemist as long as I can find my way into a most dynamic and stimulating academic environment, like that of xxx University.



My choice of biochemistry was by no means whimsical, but was defined by my intellectual curiosity and passion. In my childhood, I developed a strong interest in biology by raising various small animals—silk worms, tadpoles, and turtles whom I regularly observed to understand their behavior. To find out why one of the turtles went blind, I consulted technical literature and diagnosed the infection in the bacteria-rich water environment as the cause. I derived great pleasure from inquiring into diverse phenomena of life and the eagerness to satisfy my intellectual curiosity prompted me to study biology during my undergraduate program. As I commenced my lab research and got exposed to the cutting-edge developments in the academia, especially to those exciting but challenging subjects like structural biology that promise to furnish solutions to SARS and AIDs, my passion for biochemistry is all the more heightened. For me, nothing can satisfy my intellectual curiosity other than becoming a biochemist who is equipped to help face the common challenges of mankind. As a scientist, I hope to make my contributions that can promote the development of life science and improve the physical well-being of mankind as a whole.


The process of becoming a research student is in many important ways similar to the process of chemical reaction. For a chemical reaction, a diversity of factors is imperative to produce the desired product. In my efforts to become a research student, I have tried to develop myself in a comprehensive manner and a number of key factors have combined to make what I am.

2. 1 Academic Excellence as Foundation

A solid knowledge base in biology has been indispensible to the development of my research skills. At the Department of Biology of Nankai University, arguably one of the best universities in China, I have studied a whole gamut of specialized courses of biology, ranging from microbiology, biochemistry, genetics, to cell biology. With a major GPA reaching 86.8/100, I have been consistently ranked among the top students in the class, winning awards and scholarships. In view of biology’s relations with other sciences, I have also studied courses in physics, mathematics, computer applications that have expanded my knowledge horizon and developed interdisciplinary knowledge and skills needed for research.

2.2 Research Experiences and Achievements as Catalysts

Biology is an applied science and research is the most effective way to apply knowledge to practical problems. My outstanding academic performance landed me, in the 4th semester, in the Structural Laboratory led by the principal of our university. My participation in several research projects has enabled me to develop comprehensive research skills, to perform independent responsibilities and to seek innovative solutions. I started my research with the project “Expression of the major protein of CCR4/NOT complex using Insect expression system”, which was one of national creative projects for university students. I applied for undertaking this project out of my own initiative and I was leader of a 3-member team that worked on the expression of four key proteins (Cnot6, 6L, 7, and 8) of the complex. As the lab did not have the insect cellular expression system, I had to rely on my own efforts by consulting a large amount of technical literature and collaborating with other labs. Having expressed the complex, we did further purification and crystallization to acquire the complex’s structure with which we studied its specific deadenylation mechanism.

The second lab project involved Cnot9, one of the proteins of the complex. In order to reproduce and verify the subsidiary functions claimed by a published paper “Atomic model of human Rcd-1 reveals an armadillo-like-repeat protein with in vitro nucleic acid binding properties”, I was to reproduce crystals and soak the substrate so as to study how the protein duplicate and degrade mRNA. Following the detailed steps of the experiments, I operated in strict accordance with standard procedures and gained such techniques as expressing protein in E.coli, using molecular sieve, ion sieve, affinity chromatography, protein purification, crystallization as well as optimization. I kept maturing as a researcher.

With enhanced skills, I have embarked on even more challenging project, which is to acquire the crystal of XRN which also has the function of mRNA degradation. XRN protein’s homologous protein structure having been isolated in the yeast, I sought to obtain XRN’s structure in the human protein with a view to understanding its function. Based on literature research, I analyzed the amino acid sequence such as protein secondary structure prediction and homologous protein, and selected several segments to construct plasmid until I finally succeeded in constructing a recombinant plasmid. Through this project, I have particularly honed my lab skills in molecular construction.

As I enhanced my experiment skills, I have taken part in experiment competitions in which I have won prizes for experiment design and development of useful equipments. In those competitions, I learned how to pursue excellence by prevailing over my peers. In this way, I have been constantly motivated to face challenges and to be No. 1.

2.3 Administration Studies as Additives

As a biology student, I have a unique strength for having studied business administration at Tianjin University as a dual degree. My motivation is that biologists should not only have the abilities to carry out research but also to implement research projects which involve management and organization. My satisfactory performance in management studies testifies to my ability me to make extra achievements through extra efforts. Furthermore, I have consciously applied my management knowledge and skills in my biology research team. As project organizer and manager, I made proper task distributions and coordination, involving all the members in concerted efforts toward a common objective. Through effective synergy, I enhanced our research efficiency and I will continue to exercise productive leadership in the future.


As a biology student, I know, more than anyone else, that change is the fundamental paradigm for all forms of life and their development. For my academic development, the changes I seek are transformation and breakthrough. Given a stimulating and dynamic academic environment, I will quickly grow into an accomplished researcher.

3.1 In search for a dynamic academic environment

I am motivated toward a Ph.D. program in the U.S. because it offers the environment for the birth of outstanding biochemists. Baylor College of Medicine is precisely a cutting-edge institution in the world with unparalleled faculty and research facilities, providing ample room for aspiring students to be future leaders in the academia. I hope to study a full series of advanced courses and become exposed to high-level research projects. By working together with an outstanding faculty, I expect to publish on cutting-edge topics.

3.2 Mission

At XXX College of Medicine, I intend to focus on studying protein folding. To decipher the “second hereditary code” by means of protein structure prediction is one of the top challenges in biochemical research. By understanding the abnormalities in protein’s 3-D structure, we can make discoveries that shed light on the mad cow disease, Alzheimer's disease, and certain tumors. We know that the mad cow disease is the result of the disease-causing Prion, by means of the interaction among protein molecules, changing the normal protein Prion into disease-causing folds. But what are the nature and mechanism of this interaction? How do molecules with changed folding conditions cause serious diseases? Obviously, conventional research is unlikely to come up with effective solutions. Through future research, I hope to add to our understanding on folding diseases that can improve the health of millions of people.


As I prepare to embark on my proposed Ph.D. program, I have come to the threshold of a new phase of academic journey. I will be looking forward to developing my career and I believe XXX College of Medicine’s Ph.D. program will definitely enable me to create a milestone in my lifelong research career.



本网站所有案例及留学文书作品(包括“个人陈述”Personal Statement,“目的陈述”Statement of Purpose, “动机函”Motivation Letter,“推荐信”Recommendations / Referemces “, (小)短文”Essays,“学习计划”Study Plan,“研究计划”(Research Proposal),“签证文书”Visa Application Documents 及“签证申诉信”Appeal Letter等等),版权均为嘉文博译所拥有。未经许可,不得私自转载,违者自负法律责任。


本网站所有案例及留学文书作品(包括“个人陈述”Personal Statement,“目的陈述”Statement of Purpose, “动机函”Motivation Letter,“推荐信”Recommendations / Referemces “, (小)短文”Essays,“学习计划”Study Plan,“研究计划”(Research Proposal),“签证文书”Visa Application Documents 及“签证申诉信”Appeal Letter等等),版权均为嘉文博译所拥有。未经许可,不得私自转载,违者自负法律责任。仅供留学申请者在学习参考,不作其他任何用途。任何整句整段的抄袭,均有可能与其他访问本网站者当年递交的申请材料构成雷同,而遭到国外院校录取委员会“雷同探测器”软件的检测。一经发现,后果严重,导致申请失败。本网站对此概不负责。


电话:(010)-62968808 / (010)-13910795348

钱老师咨询邮箱:qian@proftrans.com   24小时工作热线:13910795348

版权所有 北京嘉文博译教育科技有限责任公司 嘉文博译翻译分公司 备案序号:京ICP备05038804号